Kane is back, and you have to stop him from taking over the world again... or help him achieve his goal. But this time the situation is more complicated. Due to unforeseen problems with Tiberium, a third force of Mutants (or "Shiners") now inhabit the land and are hostile to both GDI and NOD. On top of that a second Tiberium substance has been showing up in some areas with different properties to the traditional Tiberium. Once again the war between GDI and NOD rages on.