Resident Evil 4 Tips

Second El Gigante Battle Tip
OK, when he appears shoot down the boulder above with the handgun. Now run to the chained door, tell Ashley to wait and head back to the giant with the shotgun equipped.
The idea is to go to run past the giant's right side (your left) but stop if he swings round, back up a few steps and blast him. This way he won't manage to grab you so you'll avoid damage. If he doesn't swing round just run past, turn round and go again.