Prototype 2 is the direct sequel to Prototype and takes place in New York City also. The action game follows Sgt. James Heller on his quest for vengeance after the Blacklight virus took eveything from him; meanwhile, Alex Mercer is looking for the source of the outbreak.
The game is set after the events of the previous game and 14 months after Alex Mercer saved the city. Upon returning to the city, Sgt. James Heller discovers he has lost his family and sets out to slaughter as many infected as possible. His path crosses with Alex Mercer and Sgt. James Heller is infected as a result; they both seek the truth about the outbreak and must work together to bring justice to those who unleashed the virus.
It was developed by Radical Entertainment and published by Activision for the PlayStation 3, Xbox 360 and PC in 2012. It was later ported to the PlayStation 4 and Xbox One in 2015.
The gameplay is very similar to the first game and James Heller also has similar abilities to what was seen in the first game; he is able to shapeshift into people and take their memories by consuming them. Some changes have been made to his abilities however, the super-strength ability Musclemass seen in the first game has been replaced by a Tendril power which allows the player to rip through large amount of enemies. A new Biobomb ability has been added which is attached to a victim and then explodes, killing the host and damaging those nearby; this ability does not harm the player however. Sonar Pulse is a new ability that allows the player to locate specific targets and hunt them down across the city
It is possible to quick access two pre-selected powers in the middle of combat and James Heller is also able to use weapons. The powers in the game come as mutations and upgrades which the player can upgrade to and adapt to suit their playstyle.
The special abilities can be used to travel across the map; the traversing abilities seen in the first game also return for this one. The player can climb any wall, fall from great heights, sprint indefinitely, hover and more.
The infected can now be found residing in Infected Lairs inside of the Infected zones, the player can destroy infected inside of these lairs to gain mutations which can be used to upgrade James Heller. To gain mutations, the player can also hack into the Blacknet which is the communication system used by the Blackwatch.
In this game the city is split into three different colored zones. Green Zones are the safe areas established by the Blackwatch for survivors and is where life is most 'normal' after the outbreak. The Yellow Zone is a relatively safe area and survivors can be found here however, there is a nearby infected threat which demands a strong military presence to control the are. The last zone is filled with fighting, the Red Zone is the area where the player can expect to see battles between the infected and the Blackwatch.
Unlock new abilities – Upgrade and Mutate to fit any playstyle
Blow the enemy to pieces – Cause targets to explode and deal massive damage with the new Biobomb ability
Free movement – Traverse the map in a variety of ways without fear of taking damage or death
Hunt down targets – Track and hunt targets with the Sonar Pulse ability
 Players Liked
- Good graphics
- Fun abilities
- Biobomb ability
 Players Didn't Like
- Story is not very strong
- Not much replay value
- Not long enough