Whenever the next Mass Effect game arrives, we already know it won't be starring Commander Shepard. That tale is well and truly done, yet BioWare is slowly discussing what to expect in the next game. Casey Hudson is already trying to get an idea of what fans want in another Mass Effect, and recently spoke even further on what he and several other BioWare staffers would like to see done. There's actually a lot of ways it can go, even by making some spin-offs games separate from the big story.
Hudson had the following to say on what he'd like to see in a new Mass Effect:
There's so much that could be told in the Mass Effect universe. It'd be cool to do something completely unrelated to the larger storyline, like a story about a private investigator on the Citadel. Or maybe something detailing Garrus' time in C-Sec.
Dusty Everman, senior level designer at BioWare, also likes the idea of a game focused on Garrus. It's pretty easy to see why everyone's favorite turian could have his own starring role, with Everman stating:
While being one of Shepard's most loyal friends, Garrus has also had some of the most driven personal goals. He's a hero in his own right, as Archangel and beyond. Who wouldn't want to see the further adventures of the bold, charming Garrus Valkarian (there's a lot of guns out there to calibrate).
While Garrus would probably be the best candidate for many, lead designer on Mass Effect 2, Preston Watamaniuk, figures "a game centered on brutal Krogan combat with more of a melee focus could be pretty exciting."
So, Garrus or a Krogan (Wrex, anyone?) would make for an interesting game in its own right. However, Mac Walters, lead writer for the ME series, can't quite make up his mind on who he'd prefer to see. "Aria. The Illusive Man. Kai Leng. Any henchman. The list goes on. I think most of them could have successful spin-offs of their own in some fashion."
Most of those could all be considered as prequels to the Mass Effect trilogy and help to further flesh out the characters. Mike Gamble, producer for the series, would rather have a sequel starring the last surviving Prothean, Javik. "Following the story of Javik a little bit more would be pretty cool. As the last remaining member of a lost race, I think that we could tell a lot of stories about his adventures in the Milky Way, and coming to terms with his place in the new Galaxy."
A Mass Effect game focused on a single character who either had a significant part or not much of one at all in the trilogy seems to be on the minds of many at BioWare. Whether or not that's what we get remains to be seen, but it's certainly something to consider. The studio isn't nailing anything down for the new game outside of the graphics engine, so for now keep all of this as the designer's trying to figure out what's next for the series.