The VGA's played host to many debuts, including the surprising Dark Souls II announcement. Not all said debuts were necessarily for new games though, but new trailers and announcement for already known titles. Castlevania: Lords of Shadow 2, for instance, got its spotlight with a new trailer.
Unfortunately very little is out there to tell of Trevor and Simon, just that (Spoilers!) Gabriel has completed his transformation to Dracula and nothing will get in the way of his vengeance.
VGA 2012 trailer - YouTube
It's an intense clip, sure. Dracula doesn't care what year it is, or whether you're ready for his shenanigans or not. We'll have to hold out for more details to arrive next year, but it'll be a worthwhile wait.