One of the key people behind series like Mega Man and Onimusha Keiji Inafune is currently at work on his next game Soul Sacrifice, which has now been confirmed for a North American release.
Soul Sacrifice, if you've never heard of it, is an action RPG that lets you sacrifice body parts and characters for special attacks and abilities. Hey, you said you wanted innovation.
Yasunori Mitsuda (who did those wonderful Xenosaga OSTs) is working alongside Wataru Hokoyama (Afrika, Resident Evil 5) on the music and soundtrack, so that's another reason to get into it.
There's no date set yet, but we'll keep you posted.