Loosely based on the 1984 film from Columbia Pictures, Ghostbusters for the Genesis has you playing the role of Raymond, Peter or Egon as you try to rid the neighborhood of ghosts. While each character is rated differently in speed and stamina, all carry the same standard equipment: a positronic ion blaster and limited number of bombs.
The goal of the game is to retrieve pieces of a stone tablet by clearing the following houses: Home Sweet Home, Apartment, Woody House, and the High-Rise Building. Play involves shooting ghosts with your weapon and jumping to reach higher platforms or avoid hazards (such as spikes and fire). Succeed at defeating each building's boss character(s) and you'll be awarded money, which can then be used to purchase additional weapons and items.
Some of the objects you'll be able to acquire are explosives, energy tanks, barriers (each one repels attacks), three-way shots, infrared scopes (allowing you to see in the darkness), and two different types of food to replenish stamina. Items can also be found within safes scattered around the floors. After ridding all four houses of poltergeists, you'll be granted entrance into a medieval castle.
You'll then have to search for the Storm's Calm, the jewel responsible for the strange happenings around the city. Once you find it, place the jewel in a monument and prepare for the final showdown! Ghostbusters offers three levels of difficulty (easy, normal or hard) that determine the number of continues you have left before the game is over.
— Scott Alan Marriott, All Game Guide