Dr. Mario is a GameBoy port of the NES puzzle game originally release in October 1999. In Dr. Mario, players manipulate the positioning of medicine pill capsules as they gradually fall from the top and land in a giant pill bottle. The goal is to clear rows of pills by matching colors to prevent the pill bottle from overflowing, ending your game.
- Mario serves as researcher in the Mushroom Kingdom Hospital's virus research lab in this game
- Dr. Mario would later make an appearance as a playable character in Super Smash Bros. games.