Destroy All Humans! 2 Tips

Under fire? Create some cover!
There are plenty of times where Crypto will get swarmed by enemy agents with ranged weaponry. The more enemies arrive however, the more cars they bring. Use Crypto's tele-kenetic powers to lift a car (or preferably a bus) in front of himself to create cover, OR to create a choke point, jumping platform, etc. You can also place a car onto the ground in a specific area so when it blows up it works to your advantage.