Borderlands 2 Tips

Easily defeat Crystalisks
The slow but resilient Crystalisks are difficult to take down with guns early in the game, even when firing at the three weak points on their legs until they break. Fortunately, there is a much faster (and easier) way to defeat these beasts; simply use melee attacks on the weak points on each of the three legs, but only if you equip a weapons that grant bonuses to melee attacks; even a +50 percent bonus is significant.

"Law" family pistols (which are easily obtained from a side mission in Sanctuary partway through the game) are perfect examples of firearms which grant melee bonuses.