Ecks vs. Sever is the sequel to the original title Ecks vs. Sever on Game Boy Advance. Ecks and Sever have joined forces in a mission-based narrative that follows their progress as they combat a multi-national weapon-running cartel abroad and on home soil. As the story unfolds, they realize that the whole world is in extreme danger. Ecks and Sever need to get to the truth and stop a potential nuclear holocaust before it's too late.