Unlucky in love, beautiful Charlotte 'Charlie' Cantilini (Jennifer Lopez) has finally met the man of her dreams, Dr. Kevin Fields (Michael Vartan). There's just one problem - his mother. Overbearing and controlling, not to mention volatile, Viola Fields (Jane Fonda) has recently been canned from her job as a star news anchor. Fearing she will lose her son's affections as she has her career, Viola decides to break up the happy couple by becoming the world's worst mother-in-law. Helping her with her crazy schemes is Viola's long-time assistant, Ruby (Wanda Sykes). The gloves come off when Charlie finally decides to fight back and it looks like Viola has finally met her match.