Slayers-just use shiv, fire axe, or revolers.
Marksman- Use shotgun twice to kill it, or tommy gun.
Nooseman- Since these things pop out of nowhere, just use whatever. except shiv and fire axe.
Burrower-I have the shotgun or tommy gun to be most effective.
Fester-TNT, molotov, or Flamethrower
During Gameplay hold L + R + X and enter Up, Down, Left, Right.
Hold L + R + X and press Down, Up, Right, Left during game play. A message will confirm correct code entry.
When you enable the "All items and weapons" code or two or more codes, you will constantly receive images from Dr. Killjoy's room, where he has all the ink blot pictures everywhere on the walls where the man that had his eyeball taken off. To stop this side-effect, simply load a saved game before you entered the codes.
Use the following trick to defeat the creature on the last level at the dock. The big creature will smash open a gate that has a control device that will lower a machine that shoots out a purple beam. Dodge the creature's attack and stand so a beam will hit you. There is a delay between beams. After being hit, you will glow. Press R1 to throw a glowing ball. Aim for the red spot on its chest. Keep throwing balls until the creature falls in the water. If you cannot throw any more balls, stand under the beam to recharge.
Hold L + R + X and press Left, Down, Left, Down, Left, Down, A during game play. A message will confirm correct code entry.
Hold L + R + X and press Left, A(3), Right, Left, Right, Left, Up, A(3), Down, Up, Down, Up, A during game play. A message will confirm correct code entry.
Hold L + R + X and press Up, A, Left, A, Down, A, Right, A during game play. A message will confirm correct code entry. Press Start to disable this effect.
During Gameplay Hold L, R, and X then press down(3), A, up(2), down, up, A.
Press and hold L-Trigger + R-Trigger + X before putting in any codes.
Right, Right, Right, Left, Left, Left, A
Down, Down, Down, Up, Up, Up, A
Refill Current Gun Ammo:
Right, Right, Down, Up, Left, Right, Left, Left, A
Down, Down, Down, Down, A
Increase Negative Karma:
Left, Left, Down, Up, A