If you have a franchise on this game, go to the main menu of franchise mode. Once there, go down to "GM Office", then go to "Roster Management". Select "Player Editor" and use the Left Analog-stick to move left or right to find your franchise team. After finding your team, the game will show a list of all the players on it. Go down to any one of them and you will be able edit their attributes to make them the best as possible. Do this to every one of your team members to dominate the league.
Select quick play or franchise mode. Set the number of innings to 1 then score by any means while holding the CPU to a no hitter. When the single inning game ends, you will be awarded card points for having a perfect game and a no hitter.
Pause game play immediately after the pitcher releases the ball. You will be able to see the pitching icon.
In season mode, go to the GM office, then go to the player editor. Set all your players to A+ then go to all the other teams and make their All-Star players a D-.
When you play against the computer and you're pitching, leave the controller alone and let the pitcher stand there for a couple of minutes and the commentaters will start making fun of you, and other things. This works with 2 players also, you just leave both of the controllers alone.
Use the Right Analog-stick to move a pitch after it is thrown.
After you hit a home run and your player is running towards home play, press L or R. Your player will make a gesture towards the crowd. If you are playing in your home stadium, the crowd will cheer. If you are away, the crowd will boo.