Complete each achievement to get the allotted gamerscore. The numbers between the () is the points given for each achievement.
| Achievement | How to unlock |
|---|
| Practitioner (20) | Complete Chapter 1 on any difficulty. |
| Operative (20) | Complete Chapter 2 on any difficulty. |
| Specialist (20) | Complete Chapter 3 on any difficulty. |
| Master (20) | Complete Chapter 4 on any difficulty. |
| Conjurer (5) | Kill 100 Enemies while using the Dragon's Grasp. |
| Draconist (15) | Kill 400 Enemies while using the Dragon's Grasp. |
| Gunner (5) | Kill 100 Enemies while using the Minigun. |
| Heavy Operator (15) | Kill 400 Enemies while using the Minigun. |
| Breaker (5) | Kill 100 Enemies while using the Hailstorm. |
| Freezer (15) | Kill 400 Enemies while using the Hailstorm. |
| Shocker (5) | Kill 100 Enemies while using Shock Therapy. |
| Stormer (15) | Kill 400 Enemies while using Shock Therapy. |
| Lighter (5) | Kill 100 Enemies while using the Sunbeam. |
| Paladin (15) | Kill 400 Enemies while using the Sunbeam. |
| Bomber (5) | Kill 100 Enemies while using the Dream Cleaner. |
| Technician (15) | Kill 400 Enemies while using the Dream Cleaner. |
| Absolute Threshold (25) | Achieve the Gold weapon upgrade rank on the Insanity difficulty. |
| Manic Episode (15) | Enter Berserker Rage at least once in each level of the game in Story mode. |
| Aversion Therapy (15) | Complete a level on any difficulty without dying. |
| Immortal (75) | Complete every level on any difficulty without dying. |
| OCD (10) | Use every weapon at least once in any level of the game in Story mode. |
| Latent Abilities (25) | Complete every level on any difficulty without dying in the Subconscious. |
| Opiophobia (25) | Complete one level without receiving any Health pickups. |
| Wisdom (15) | Find and enter in all of the Secret areas in any one level of the game. |
| Poor Sleeper (15) | Complete Story mode on the Bad Dream difficulty. |
| Somnambulist (25) | Complete Story mode on the Nightmare difficulty. |
| Lucid Guardian (45) | Complete Story mode on the Insanity difficulty. |
| Rhabdophobia (25) | Complete one level in Story mode while only using the Dragon's Grasp. |
| Hoplophobia (25) | Complete one level in Story mode while only using the Minigun. |
| Pagophobia (25) | Complete one level in Story mode while only using the Hailstorm. |
| Astraphobia (25) | Complete one level in Story mode while only using Shock Therapy. |
| Heliophobia (25) | Complete one level in Story mode while only using the Sunbeam. |
| Ligyrophobia (25) | Complete one level in Story mode while only using the Dream Cleaner. |
| Psychoanalysis (15) | Kill 25 opponents in any Multiplayer game mode. |
| Prescription (30) | Kill 100 opponents in any Multiplayer game mode. |
| Treatment (50) | Kill 300 opponents in any Multiplayer game mode. |
| Instinctual Action (25) | Enter Berserker Rage during a Multiplayer game. |
| Untouchable (30) | Kill 10 opponents in a row without dying in a Multiplayer game. |
| Free Association (15) | Kill 3 or more opponents at the same time in a Multiplayer game. |
| Xenophobia (15) | Kill 10 or more enemies at the same time with any weapon. |
| Focused Mind (10) | Defeat a Doorkeeper without taking any damage. |
| Dreamkiller (20) | Defeat a Dreamkiller without taking any damage. |
| Delusions of Grandeur (25) | Finish a Deathmatch game with the highest score (with at least 3 other players involved). |
| Mind Guard (25) | Return your team's flag at least 5 times in one CTF match. |
| Mastermind (25) | Conquer 50 brains in Conquest mode. |
| Psycho Logical (25) | Complete a Single Player game in Time Trial mode. |
| Simple Jack (25) | Complete a Single Player game in Single Weapon mode. |
| Secret Achievements | - |
