Complete each achievement to get the allotted gamerscore. The numbers between the () is the points given for each achievement.
| Achievement | How to unlock |
| Cloak & Daggers(10) | Deal with the man in the shadows. |
| Smash the State(10) | Help Officer Nicholas take out the trash. |
| Acquaintances Forgotten(10) | Follow Pritchard's lead to uncover the truth. |
| Doctorate(50) | Read all 29 unique XP books within a single playthrough. |
| Lesser Evil(10) | Deal with Mr. Carella's indiscretion. |
| Motherly Ties(10) | Put a grieving mother's doubts to rest. |
| Corporate Warfare(10) | Protect a client's interests by performing a less-than-hostile takeover. |
| Talion A.D.(10) | Descend into the bowels of an urban jungle and confront a warrior-priest. |
| Gun Nut(20) | Fully upgrade one of your weapons. |
| Bar Tab(10) | Help the Hive Bartender settle a tab. |
| Rotten Business(10) | Help a lady in the oldest of professions clean house. |
| Shanghai Justice(10) | It may take some sleuthing, but justice must be served. |
| Hax0r1!(15) | Successfully hack 50 devices within the same playthrough. |
| Transhumanist(5) | Fully upgrade your first augmentation of choice. |
| Consciousness is Over-rated(15) | Knock out 100 enemies in a single playthrough. |
| First Takedown(5) | Perform your first Takedown. Civilians don't count, so be nice. |
| Opportunist(15) | Perform 50 takedowns within the same playthrough. (Civilians don't count.) |
| First Hack(5) | Perform your first Hack successfully. |
| Deus Ex Machina(50) | Experience all the different endings that Deus Ex: Human Revolution has to offer. |
| Legend(100) | Complete Deus Ex: Human Revolution at its hardest setting without ever changing the difficulty. |
| Pacifist(100) | Complete Deus Ex: Human Revolution without anyone dying by your hand. (Boss fights don't count.) |
| Foxiest of the Hounds(100) | Complete Deus Ex: Human Revolution without setting off any alarms. |
| Up the Ante!(15) | Upgrade your first weapon of choice. |
| Trooper(50) | Complete Deus Ex: Human Revolution. |
| Legend(100) | Complete Deus Ex: Human Revolution at its hardest setting without ever changing the difficulty. |
| DLC Achievements | The Missing Link |
| Factory Zero (70) | You survived The Missing Link using no Praxis kits, weapons, or explosives. Whoa. |
| Never Stop Looking (20) | You escaped Rifleman Bank Station. Nothing will stop you from finding Megan now. |
| Secret DLC Achievements | The Missing Link |
| Good Samaritan (20) | Replace the power supply on a damaged stasis pod, saving the occupants life. |
| Never Forget (20) | Revisit the site where Belltower discovered and captured you. |
| Out of the Frying Pan (20) | Make it off the boat... but to what end? |
| The learn'd Scholar (20) | Collect the tree collectables, and place them on the holograph tables in the lab. |
| All of the Above (20) | Save Dr. Kavanagh and all the prisoners. |
| Back Stage Pass (20) | Gain access to Quinn's secret store. |
| Apex Predator (20) | Perform a takedown on Burke without being detected. |
| That Old Adage (20) | Talk to Quinn on the harbor, and attempt to use the CASIE persuasion augmentation. |