When falling from a great height and about to take damage, perform the Ground Pound attack just before you hit the ground. If timed correctly, it will break your fall and you will not sustain any damage.
In Dragons Reach (level 2), climb up the dragon's tail. Continue climbing until you reach the yellow poles on the slippery ground. Climb the first and jump to the others. On the last one, turn to your left and try to do a long jump to a small platform with a jump pad on it. You will be rocketed over to the plateau. Walk around it. The fly suit is on the other side. Note that the jump to the jump pad may require some adjustments on your part.
In the pirate ship game with the three pirates from the belly of the large beast, it is easier to not try to change the colors of the squares yourself. Instead, watch the board and let the cannonballs do the work for you.
When doing the Square(3) combo, press the buttons slowly and the third attack will be a ground piercing attack that you can follow up with an uppercut by pressing Square. If you hold Square on the third hit, Vexx will power up for a more powerful attack, and his uppercut will send him into the air.
After the Talon's tutorial, when the blind guy wakes you up, jump to the column in the middle that has fire on it, but do not touch the fire. After that, arrange yourself so that you are on the left side facing the exit. Hop into the fire, and rocket yourself out to the left. Proceed towards the blue rings. You will be teleported to the red tapestry. Climb to the top of it and grab the red disk. Afterwards, jump off either side to exit the tapestry.
In Daggercrag, once you adjust the sundial, go to the base with the ring full of enemies. Climb the second pole to the right and you should find a sundial portal. Go through it if you see another world in it. Note: Be careful, as this stage is extremely tricky.
Use combos to increase the super move meter in the top right corner. After it is flashing, press R1 to execute a super move.
Go to Timberdale. Go to the sundial. Set it to either of the golden dots (sunrise or sunset). Quickly get back to the hub and enter the Shadowrealm. The ending sequence will be different, with Vexx will flipping off Yabu.
Enter XXEVREWOP as a code at the cheats screen.
If you found a diary page or an extra life and need a quick way to save but cannot find a new heart, do not collect a heart you previously acquired. Instead, go to Darby's house on Timberdale. Teleport into the picture and pick up the Crimson Key. This works with the Air Suit, but Timberdale is quicker.