One particularly rewarding method of play is to master the double jump directly over an enemy. If you can leap into the air and track an enemy target, it's a total advantage for you to fire at them while they stop and turn around. It's also harder for shooting enemies to draw a bead on you as a result.
Click the Right Analog-stick to activate your blood vision.
Be careful while fighting banshees. If you cut off their arms and they still live, they will fire non-stop energy balls at you.
While fighting Lazaurus for the final time, hide in the house when he is using his twister move; it will shield you. Also, when he shoots his fireballs and smoke clouds, shoot them; they will blow up and you will be unharmed.
Click the Left Analog-stick to duck.
Blood Frenzy: Adds a supernatural boost to hand-to-hand combat.
Black Shroud: Covers you in a black shroud of darkness that hurts enemies when they attack for a short time.
Immortal Friends: No matter how many times you shoot Cassidy or Tala, they will not die.
Soul Stealer: Sucks the souls right out of living enemies (can be used at a distance).
Turn: Turns some enemies against each other for a short period of time.
Fear: Some enigmas will run scared for a short time.
Mystic Armor: Strong armor (possible 0 damage) for a short time.
Silver Bullet: Infinite and more powerful bullets for a short time.
Vindicator: Shoots a chain of lighting that instantly destroys most small monsters.
Hold two weapons:
Press Down to switch to your second weapon slot. This is useful if you are saving a rail rocket or shotgun. Also, press Up to switch between dynamite and splitter grenades (if available).
While fighting a group of enigmas and there is a Dark Mark (Evil Tree), quickly destroy the tree before fighting any enemies. When it is destroyed, it will shoot a shockwave, instantly destroying all enemies in that area.
Hold down the fire button (R) on the pistol (Redeemer) to fan it, or shoot in rapid fire.