| Unlockable | How to unlock |
|---|
| Absolute Threshold | Achieve the Gold weapon upgrade rank on the Insanity difficulty. |
| Astraphobia | Complete one level in Story mode while only using Shock Therapy. |
| Aversion Therapy | Complete a level on any difficulty without dying. |
| Bomber | Kill 100 Enemies while using the Dream Cleaner. |
| Breaker | Kill 100 Enemies while using the Hailstorm. |
| Conjurer | Kill 100 Enemies while using the Dragon's Grasp. |
| Delusions of Grandeur | Finish a Deathmatch game with the highest score (with at least 3 other players involved). |
| Dissociative Disorder | Kill 25 Enemies while teleporting. |
| Draconist | Kill 400 Enemies while using the Dragon's Grasp. |
| Dreamkiller | Defeat a Dreamkiller without taking any damage. |
| Focused Mind | Defeat a Doorkeeper without taking any damage. |
| Free Association | Kill 3 or more opponents at the same time in a Multiplayer game. |
| Freezer | Kill 400 Enemies while using the Hailstorm. |
| Gunner | Kill 100 Enemies while using the Minigun. |
| Hallucinations | Die 5 times while in the Subconscious. |
| Heavy Operator | Kill 400 Enemies while using the Minigun. |
| Heliophobia | Complete one level in Story mode while only using the Sunbeam. |
| Hoplophobia | Complete one level in Story mode while only using the Minigun. |
| Immortal | Complete every level on any difficulty without dying. |
| Xenophobia | Kill 10 or more enemies at the same time with any weapon. |
| Instinctual Action | Enter Berserker Rage during a Multiplayer game. |
| Latent Abilities | Complete every level on any difficulty without dying in the Subconscious. |
| Lighter | Kill 100 Enemies while using the Sunbeam. |
| Ligyrophobia | Complete one level in Story mode while only using the Dream Cleaner. |
| Lucid Guardian | Complete Story mode on the Insanity difficulty. |
| Manic Episode | Enter Berserker Rage at least once in each level of the game in Story mode. |
| Master | Complete Chapter 4 on any difficulty. |
| Mastermind | Conquer 50 brains in Conquest mode. |
| Mind Guard | Return your team's flag at least 5 times in one CTF match. |
| OCD | Use every weapon at least once in any level of the game in Story mode. |
| Operative Complete | Chapter 2 on any difficulty. |
| Opiophobia | Complete one level without receiving any Health pickups. |
| Pagophobia | Complete one level in Story mode while only using the Hailstorm. |
| Paladin | Kill 400 Enemies while using the Sunbeam. |
| Poor Sleeper | Complete Story mode on the Bad Dream difficulty. |
| Practitioner | Complete Chapter 1 on any difficulty. |
| Prescription | Kill 100 opponents in any Multiplayer game mode. |
| Psycho Logical | Complete a Single Player game in Time Trial mode. |
| Psychoanalysis | Kill 25 opponents in any Multiplayer game mode. |
| Rhabdophobia | Complete one level in Story mode while only using the Dragon's Grasp. |
| Shocker | Kill 100 Enemies while using Shock Therapy. |
| Simple Jack | Complete a Single Player game in Single Weapon mode. |
| Somnambulist | Complete Story mode on the Nightmare difficulty. |
| Specialist | Complete Chapter 3 on any difficulty. |
| Stormer | Kill 400 Enemies while using Shock Therapy. |
| Suicidal Tendencies | Die 10 times to self-inflicted explosives fire in any Single Player mode. |
| Technician | Kill 400 Enemies while using the Dream Cleaner. |
| Treatment | Kill 300 opponents in any Multiplayer game mode. |
| Untouchable | Kill 10 opponents in a row without dying in a Multiplayer game. |
| Wisdom | Find and enter in all of the Secret areas in any one level of the game. |
