To unlock difficulty setting (harder than Hard), press A, B, SELECT, UP, RIGHT, DOWN at the title screen. Prepare for a tough, tough challenge.
After Mysterio: C3K23M
After Sandman: T4Q59J
After Vulture: MM947F
After Scorpion: TS6!96
After Kraven: LR6!9G
At the title screen, press A, B, A, B, Down.
To get infinite life, you want to press UP, DOWN, RIGHT, A at the title screen.
To enable the Web O' Death, enter the following button presses at the title screen: DOWN, A, B, A, A. Now, when you begin your game, Spidey's web ball attack will kill on contact.
To eliminate the need to collect web canisters, enter the following button presses at the title screen: LEFT, DOWN, B, UP. The web will flow freely.
To skip a level, press B, A, LEFT, DOWN, UP, RIGHT at the title screen. You'll be taken to a screen where you can select your level --from 1 to 18.
To unlock the bonus mini-game, press A, B, A, B, DOWN at the title screen. You'll be taken to a game where Spidey and Doc Ock have to move a trampoline around, bouncing teddy bears from one side of the screen to the other.