Against the Fire! takes place in the city of Waterfront where strange “fire ball monsters” live and cause havoc by producing massive fires. All hell breaks loose and the Waterfront fire department is suddenly swamped with endless fires to attend to. Your character Andrew, a firefighter trainee without any experience, is ordered to stay behind at the headquarters. However, the siren goes off while he is at the station alone and it turns out the alarm is coming from the hotel right next to the headquarters! A huge number of hotel guests are trapped inside the hotel as the fire ball monsters loom outside attacking. Not wanting to stand aside, Andrew has no choice but to rescue them from the fire scene!