In Rampage, you assume the guise of a large ape the size of King Kong (George) or that of a gargantuan lizard very much resembling Godzilla (Lizzie). The citizens of America see you as a menace and just want you dead. So why not just destroy the country town-by-town? Explore all of the U.S. -- from Detroit down to Houston, from New York to L.A. Climb buildings and punch through open windows to grab food for health, potions for invincibility, or humans for tasty snacks! Of course, the armed forces aren't standing idly by while you destroy each city! You'll have to deal with helicopters, tanks, explosives and troops firing at you. Once your health bar is gone, you'll revert back to your human form and lose a life.

— Christopher Michael Baker, All Game Guide
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